Methods for particle size reduction of liposomal amphotericin B

Main Article Content

Tuan Quang Nguyen Van Lam Nguyen Thai Son Nguyen Thi Minh Hue Pham

Abstract

Liposomal amphotericin B were prepared by thin film hydration technique. Particle size was reduced by ultrasonic device and high-pressure homogeneous device. The size distribution was determined by dynamic light scattering by the Zetasizer ZS90 equipment. The morphology of amphotericin B liposomes was observed by Transmission electronic microscopy (TEM) with negative staining technique. The result shows that combining high-pressure homogenization and membrane extrusion provided monolayer liposomal amphotericin B with the particle size less than 200 nm and homogeneously (PDI < 0.3).

 

DOI: https://doi.org/10.31276/VJSTE.60(1).42

Article Details

How to Cite
NGUYEN, Tuan Quang et al. Methods for particle size reduction of liposomal amphotericin B. Vietnam Journal of Science, Technology and Engineering, [S.l.], v. 60, n. 1, p. 42-45, mar. 2018. ISSN 2525-2461. Available at: <http://vietnamscience.vn/index.php/VJSTE/article/view/105>. Date accessed: 19 aug. 2018.
Section
LIFE SCIENCES