The effects of temperature, feed ratio, and reaction time on the properties of copolymer PLA-PEG-PLA

Main Article Content

Viet Linh Nguyen-Vu Mai Anh Pham Dai Phu Huynh

Abstract

Triblock copolymers were polymerised by the ringopening reaction of D,L-lactide in the presence of poly(ethylene glycol) (PEG), with number-average molecular weight (Mn) of 1500 and 2050 g/mol, using Sn(Oct)2 as a catalyst. The influences of the reaction time, the ratio of PEG and Poly(D,L-lactic acid) (PLA), and PEG types on structure and sol-gel phase transition of PLA-PEG-PLA triblock copolymers were investigated. Optimal polymerisation parameters were obtained, such as reaction time of 18 hours, a catalyst amount of 1.3%, and PEG/PLA ratio of 1/1.7, PEG (Mn=1500); the efficiency of the triblock synthesis was 42.3%. The properties of PLA-PEG-PLA copolymers were evaluated by analytical methods such as proton nuclear magnetic resonance H1NMR spectroscopy, gel permeation chromatography (GPC), and the sol-gel state transition at varying temperature. The results show that the triblock was successfully synthesised and its hydrogel had capability of the sol-gel state transition when the temperature changed. The PLA-PEG-PLA copolymer in aqueous solution is a thermo-sensitive hydrogel that can be used for drug and protein delivery systems or triblock denaturation applications for commercial purposes.

 

DOI: https://doi.org/10.31276/VJSTE.61(1).09-13

Article Details

How to Cite
NGUYEN-VU, Viet Linh; PHAM, Mai Anh; HUYNH, Dai Phu. The effects of temperature, feed ratio, and reaction time on the properties of copolymer PLA-PEG-PLA. Vietnam Journal of Science, Technology and Engineering, [S.l.], v. 61, n. 1, p. 9-13, mar. 2019. ISSN 2525-2461. Available at: <http://vietnamscience.vn/index.php/VJSTE/article/view/185>. Date accessed: 20 may 2019.
Section
PHYSICAL SCIENCES