Huu Song Le

Name                                                   Huu Song Le  

Date of Birth                                       May 02.1970

Place of Birth                                      Hatinh, Vietnam

Nationality                                           Vietnam

Present address                                 108 Military Central Hospital, Hanoi, Vietnam

Telephone number                            + 84 (0) 69 698713

Telefax                                                  + 84 (0) 439728027

Mobile:                                                  + 84 (0) 974845270

E-mail                                                     lehuusong@108-icid.com      

Marital status                                       Married, two children.

 

Education and Professional qualifications

10/2014 - now : Deputy Director, 108 Institute of Clinical Medical and Pharmaceutical Sciences (108 Military Central Hospital), Hanoi, Vietnam

2/2014-now: Head, Faculty of Infectious and Tropical Diseases, 108 Institute of Clinical Medical and Pharmaceutical Sciences

2/2014-5/2015 : Director, Institute of Clinical Infectious Diseases, Tran Hung Dao Hospital, Hanoi, Vietnam

4/2007-2/2014 : Head, Department of Molecular Biology, Tran Hung Dao Hospital, Hanoi, Vietnam

6/2004-4/2007: Physician, postdoctoral at the Dept of Infectious Diseases, Tran Hung Dao Hospital, Hanoi, Vietnam

1/2006-2/2006: Training course on HIV/AIDS care program in USA and Thailand

10/2003-6/2004: Postdoctoral at the Dept of Molecular Pathology, Institute of Pathology, Uni Tubingen, Germany

2001-10/2003: PhD student at Faculty of Biology, Uni-Tubingen, Germany. Doctor of Phylosophy (PhD)

10/1999-4/2001: PhD student in Vietnam Military Medical University, Hanoi, Vietnam

10/1994-10/1999: Physician at the Dept of Infectious Diseases, Tran Hung Dao Hospital, Hanoi, Vietnam

1988-1994: Vietnam Military Medical University, Hanoi, Vietnam Medical Doctor (MD)

1986: Tran Phu School, Hatinh, Vietnam. General Cerfiticate of Secondary Education

 

Awards

DAAD Fellowship award in Institute of Tropical Medicine, University of Tubingen, Germany from April 2001 to October 2003.

 

Cooperations with Germany

Institute of Tropical Medicine, University of Tubingen, Tubingen, Germany

DAAD-PAGEL- Etablierung infektiologischer Diagnostikverfahren in Hanoi, Vietnam, im Rahmen einer Hochschulpartnerschaft. Forderperiode 2015 - 2018.

 

Publications

  1. Ngo TT, Hoang VT, Tran TL, Trinh VS, Tran TTH, Dao TQ, Phan QH, Meyer CG, Song LH. Clinical utility of an optimised multiplex real-time PCR assay for the identification of pathogens causing sepsis in Vietnamese patients. Int J Infect Dis. 2017 Dec 15. pii: S1201-9712(17)30327-2. doi: 10.1016/j.ijid.2017.12.015. [Epub ahead of print]
  2. Amorim LM, van Tong H, Hoan NX, Vargas LB, Ribeiro EMSF, Petzl-Erler ML, Boldt ABW, Toan NL, Song LH, Velavan TP, Augusto DG. KIR-HLA distribution in a Vietnamese population from Hanoi. Hum Immunol. 2017 Nov 27. pii: S0198-8859(17)30552-9. doi: 10.1016/j.humimm.2017.11.011. [Epub ahead of print]
  3. Lucas Sandri T, Adukpo S, Giang DP, Nguetse CN, Antunes Andrade F, Tong HV, Toan NL, Song LH, Elumalai P, Thangaraj K, Valluri VL, Ntoumi F, Meyer CG, Jose de Messias Reason I, Kremsner PG, Velavan TP. Geographical distribution of complement receptor type 1 variants and their associated disease risk. PLoS One. 2017 May 17;12(5):e0175973.
  4. Hoan NX, Van Tong H, Giang DP, Cuong BK, Toan NL, Wedemeyer H, Bock CT, Kremsner PG, Song LH, Velavan TP. SOCS3 genetic variants and promoter hypermethylation in patients with chronic hepatitis B. Oncotarget. 2017 Mar 7;8(10):17127-17139.
  5. Trung NT, Van Son T, Quyen DT, Anh DT, Sang VV, Lam NX, Manh ND, Duong VP, Cuong BT, Tuyen QD, Chinh NX, Hoan PQ, Van Tong H, Meyer CG, Song LH. Significance of nucleic acid testing in diagnosis and treatment of post-neurosurgical meningitis caused by multidrug-resistant Acinetobacter baumannii: a case report. J Med Case Rep. 2016 Nov 3;10(1):313.
  6. Trung NT, Hien TT, Huyen TT, Quyen DT, Van Son T, Hoan PQ, Phuong NT, Lien TT, Binh MT, Van Tong H, Meyer CG, Velavan TP, Song le H. Enrichment of bacterial DNA for the diagnosis of blood stream infections. BMC Infect Dis. 2016 May 31;16:235.
  7. Hoan NX, Khuyen N, Binh MT, Giang DP, Van Tong H, Hoan PQ, Trung NT, Anh DT, Toan NL, Meyer CG, Kremsner PG, Velavan TP, Song LH. Association of vitamin D deficiency with hepatitis B virus - related liver diseases. BMC Infect Dis. 2016 Sep 23;16(1):507.
  8. Hoan NX, Van Tong H, Giang DP, Toan NL, Meyer CG, Bock CT, Kremsner PG, Song LH, Velavan TP. Interferon-stimulated gene 15 in hepatitis B-related liver diseases. Oncotarget. 2016 Sep 10.
  9. Hoan NX, Tong HV, Hecht N, Sy BT, Marcinek P, Meyer CG, Song le H, Toan NL, Kurreck J, Kremsner PG, Bock CT, Velavan TP. Hepatitis E Virus Superinfection and Clinical Progression in Hepatitis B Patients. EBioMedicine. 2015 Nov 11;2(12): 2080-6.
  10. Trung NT, Thu Hien TT, Thanh Huyen TT, Quyen DT, Hoan PQ, Velavan TP, Song LH (2015). Simple multiplex PCR assays to detect common pathogens and associated genes encoding for acquired extended spectrum betalactamases (ESBL) or carbapenamases from surgical site infected specimens in Vietnam. Annals of Clinical Microbiology and Antimicrobials 2015, 14:23.
  11. Tong HV, Song LH, Hoan NX, Cuong BK, Sy BT, Son HA, Quyet D, Binh VQ, Kremsner PG, Bock C-T, Velavan TP, Toan NL (2015). Soluble MICB protein levels and platelet counts during hepatitis B virus infection and response to hepatocellular carcinoma treatment. BMC Infectious Diseases 2015, 15:25.
  12. Sy BT, Nguyen HM, Toan NL, Song LH, Tong HV, Wolboldt C, Binh VQ, Kremsner PG, Velavan TP, Bock CT. Identification of a natural intergenotypic recombinant hepatitis delta virus genotype 1 and 2 in Vietnamese HBsAg-positive patients. Journal of Viral Hepatitis 2015 Jan;22(1):55-63.
  13. Sy BT, Ratsch BA, Toan NL, Song le H, Wollboldt C, Bryniok A, Nguyen HM, Luong HV, Velavan TP, Wedemeyer H, Kremsner PG, Bock CT. High prevalence and significance of hepatitis D virus infection among treatment-naïve HBsAg-positive patients in Northern Vietnam. PLoS One. 2013 Oct 18;8(10):e78094. doi: 10.1371/journal.pone.0078094. eCollection 2013.
  14. Toan NL, Sy BT, Song le H, Luong HV, Binh NT, Binh VQ, Kandolf R, Velavan TP, Kremsner PG, Bock CT. Co-infection of human parvovirus B19 with Plasmodium falciparum contributes to malaria disease severity in Gabonese patients. BMC Infect Dis. 2013 Aug 15;13:375. doi: 10.1186/1471-2334-13-375.
  15. Tong HV, Toan NL, Song LH, Bock CT, Kremsner PG, Velavan TP.  Hepatitis B virus-induced hepatocellular carcinoma: functional roles of MICA variants.  J Viral Hepat. 2013 Oct;20(10):687-98. doi: 10.1111/jvh.12089. Epub 2013 May 7.
  16. Clark A, Gerlach F, Tong HV, Hoan NX, Song LH, Toan NL, Bock CT, Kremsner PG, Velavan TP. A trivial role of STAT4 variant in chronic hepatitis B induced hepatocellular carcinoma. Infect Genet Evol. 2013 Jun 6. doi:pii: S1567-1348(13)00222-0.
  17. Tong HV, Toan NL, Song LH, Bock CT, Kremsner PG, and Velavan TP. Hepatitis B virus-induced hepatocellular carcinoma: functional roles of MICA variants. Journal of Viral Hepatitis, 2013. Received September 2012; accepted for publication January 2013.
  18. Aditya Nath Jha, Vipin Kumar Singh, Namrata Kumari, Ashish Singh, Justin Antony, Hoang van Tong, Sakshi Singh, Sudhanshu S. Pati, Pradeep K. Patra, Rajender Singh, Nguyen L. Toan, Le H. Song, Amal Assaf, Iara J. T. Messias–Reason, Thirumalaisamy P. Velavan, Lalji Singh, Kumarasamy Thangaraj. IL-4 Haplotype -590T, -34T and Intron-3 VNTR R2 Is Associated with Reduced Malaria Risk among Ancestral Indian Tribal Populations. PLOS ONE, 1 October 2012, Volume  7, Issue  10, e48136.
  19. Ojurongbe O, Abou Ouf E, Van Tong H, Toan NL, Song LH, Luz PR, Messias-Reason IJ, Nurjadi D, Zanger P, Kun JF, Kremsner PG,Velavan TP. Reliable and rapid characterization of functional FCN2 gene variants reveals diverse geographical patterns. BMC Med Genet. 2012 May 17;13(1):37. [Epub ahead of print].
  20. Tong HV, Toan NL, Song le H, Ouf EA, Bock CT, Kremsner PG, Kun JF, Tp Velavan. Ficolin-2 Levels and FCN2 Haplotypes Influence Hepatitis B Infection Outcome in Vietnamese Patients. PLoS One. 2011;6(11):e28113.
  21. Tong HV, Toan NL, Song LH, Kremsner PG, Kun JF, Tp V. Association of CISH -292A/T genetic variant with hepatitis B virus infection. Immunogenetics. 2012 64(4):261-5.
  22. Bang MH, VAN Riep T, Thinh NT, Song LH, Dung TT, VAN Truong L, VAN Don L, Ky TD, Pan D, Shaheen M, Ghoneum M. Arabinoxylan Rice Bran (MGN-3) Enhances the Effects of Interventional Therapies for the Treatment of Hepatocellular Carcinoma: A Three-year Randomized Clinical Trial. Anticancer Res. 2010 Dec;30(12):5145-5151.
  23. Nguyen TL, Uchida T, Tsukamoto Y, Trinh DT, Ta L, Mai BH, Le H Song (Le SH), Thai KD, Ho DD, Hoang HH, Matsuhisa T, Okimoto T, Kodama M, Murakami K, Fujioka T, Yamaoka Y, Moriyama M. Helicobacter pylori infection and gastroduodenal diseases in Vietnam: a cross-sectional, hospital-based study. BMC Gastroenterol. 2010 Sep 30;10:114.
  24. Nguyen LT, Uchida T, Tsukamoto Y, Trinh TD, Ta L, Mai HB, Le H Song (Le HS), Ho DQ, Hoang HH, Matsuhisa T, Okimoto T, Kodama M, Murakami K, Fujioka T, Yamaoka Y, Moriyama M. Clinical relevance of cagPAI intactness in Helicobacter pylori isolates from Vietnam. Eur J Clin Microbiol Infect Dis. 2010 Jun;29(6):651-60.
  25. Bock CT, Toan NL, Koeberlein B, Song le H, Chin R, Zentgraf H, Kandolf R, Torresi J. Subcellular mislocalization of mutant hepatitis B X proteins contributes to modulation of STAT/SOCS signaling in hepatocellular carcinoma. Intervirology. 2008;51(6):432-43.
  26. Song le H, Xuan NT, Toan NL, Binh VQ, Boldt AB, Kremsner PG, Kun JF. Association of two variants of the interferon-alpha receptor-1 gene with the presentation of hepatitis B virus infection. Eur Cytokine Netw. 2008 Dec;19(4):204-10.
  27. Tena-Tomás C, de Messias-Reason I, Song le H, Tomiuk J, Kemsner PG, Kun JF. A globally occurring indel polymorphism in the promoter of the IFNA2 gene is not associated with severity of malaria but with the positivity rate of HCV. BMC Genet. 2008 Dec 3;9:80.
  28. Le H. Song, Toan NL, Xuan NT, Uhlemann AC, Boldt AB, Duy DN, Binh VQ, Kremsner PG, Kun JF. A promoter polymorphism in the interferon alpha-2 gene is associated with the clinical presentation of hepatitis B. Mutat Res. 2006 Oct 10;601(1-2):137-43.
  29. Nguyen L. Toan, Le H. Song, Peter G. Kremsner, Dinh N. Duy, Vu Q. Binh, Bernd Koeberlein, Stefan Kaiser, Reinhard Kandolf, Joseph Torresi, and C.-Thomas Bock. Impact of the Hepatitis B Virus Genotype and Genotype Mixtures on the Course of Liver Disease in Vietnam. Hepatology, 2006;43:1375-1384.
  30. Nguyen L. Toan, Le H. Song, Peter G. Kremsner, Dinh N. Duy, Vu Q. Binh, Anja Duechting, Heike Kaiser, Joseph Torresi, Reinhard Kandolf, C.-Thomas Bock. Co-infection of human parvovirus B19 in Vietnamese patients 3 with hepatitis B virus infection. J Hepatol. 2006 Sep;45(3):361-9. Epub 2006 Apr 27.
  31. Toan NL, Duechting A, Kremsner PG, Song le H, Ebinger M, Aberle S, Binh VQ, Duy DN, Torresi J, Kandolf R, Bock CT. Phylogenetic analysis of human parvovirus B19, indicating two subgroups of genotype 1 in Vietnamese patients. J Gen Virol. 2006 Oct;87(Pt 10):2941-9.
  32. Le H. Song, Dinh N. Duy, Vu Q. Binh, Adrian J. F Luty, Peter G. Kremsner and C. Thomas Bock. Low frequency of mutation in the X-gene, Core Promoter and Pre-Core region of hepatitis B virus in infected -Vietnamese. J Viral Hepat. 2005 Mar;12(2):160-7.
  33. Mörmann M, Rieth H, Hua T-D, Assohou C, Roupelieva M, Le H. Song, Kremsner PG, Luty AJF, Kube D. Mosaics composed of single nucleotide polymorphisms or dinucleotide repeats in the distal IL-10 gene 5’-flanking region affect IL-10 production differently in EBV-immortalised B cells and cAMP-or LPS stimulated leukocytes. Genes Immun. 2004 Jun;5(4):246-55.
  34. Le H. Song, Vu Q. Binh, Dinh N. Duy, Thomas C. Bock, Peter G. Kremsner, Adrian J. F. Luty and Elie Mavoungou. Variations in the serum concentrations of soluble Fas and soluble Fas ligand according to clinical status in Vietnamese infected with hepatitis B virus. Journal of Medical Virology. 2004, 73: 244-249.
  35. Le H. Song, Vu Q. Binh, Dinh N. Duy, Jürgen F. Kun, Thomas C. Bock, Peter G. Kremsner and Adrian J. F. Luty. Serum cytokine profiles associated with clinical presentation in Vietnamese infected with hepatitis B virus. Journal of Clinical Virology. 2003: 28: 93-103.
  36. Le H. Song, Vu Q. Binh, Dinh N. Duy, Simone Jüliger, Thomas C. Bock, Adrian J. F. Luty, Peter G. Kremsner and Jürgen F. J. Kun. Mannose-binding lectin gene polymorphisms and hepatitis B virus infection in Vietnamese patients. Mutation Research. 2003; 522: 119-125.

 

Following people are prepared to answer questions as to my person and my qualifications:

  • Dr. Peter G. Kremsner, Director, Institute of Tropical Medicine, University of Tuebingen, Germany. Email: peter.kremsner@uni-tuebingen.de
  • Thirumalaisamy P. Velavan, Group leader, Institute of Tropical Medicine, University of Tuebingen, Germany. Email: Velavan@medicine.uni-tuebingen.de
  • Dr. Thomas C. Bock, Director and Professor, Head, Viral Gastroenteritis and Hepatitis Pathogens and Enteroviruses. Robert Koch-Institute, Germany. E-mail: bockc@rki.de