Neuroprotective effects of Diospyros kaki and Gardenia jasminoides against ischemic neuronal injury in mice

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Thi Xoan Le Thi Nguyet Hang Pham Van Tai Nguyen Viet Dung Le

Abstract

This study aims to clarify the neuroprotective effects of ethanol extracts of Diospyros kaki (DK) leaves and Gardenia jasminoides (GJ) fruit on cerebral ischemia injury using middle cerebral artery occlusion (MCAO) model in mice. Swiss albino mice were daily treated with DK extract (125-500 mg/kg b.w) and GJ extract (250-1,000 mg/kg b.w) for 1 week before being subjected to MCAO. The administration of edaravone (6 mg/kg, i.v), which was a reference drug, was started immediately after MCAO. DK and edaravone treatment improved neurological deficits and reduced infarct volume of MCAO mice compared to that of a vehicle-treated one. GJ treatment improved neurological deficits, but did not affect the infarct volume of MCAO mice. These results suggested that the DK and GJ treatment might be beneficial for protecting the neuronal system against cerebral ischemic injury.

Article Details

How to Cite
LE, Thi Xoan et al. Neuroprotective effects of Diospyros kaki and Gardenia jasminoides against ischemic neuronal injury in mice. Vietnam Journal of Science, Technology and Engineering, [S.l.], v. 59, n. 3, p. 60-64, sep. 2017. ISSN 2525-2461. Available at: <http://vietnamscience.vn/index.php/vistech/article/view/71>. Date accessed: 15 dec. 2017.
Section
LIFE SCIENCES